Pharyngitis / tonsillitis caused by Streptococcus pyogenes Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase-producing strains), Moraxella catarrhalis (including beta lactamase- producing strains) or Streptococcus pyogenes. Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non beta-lactamase lactamase producing strains only) Lower respiratory tract infections including pneumoniae caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase and non-penicillinase-producing strains), Streptococcus pyogenes, Escherichia coli. Acute bacterial exacerbations of chronic bronchitis and secondary bacterial infections of acute bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae (beta-lactamase negative strains), or Haemophilus para-influenzae (beta-lactamase negative strains). Skin and Skin-Structure infections caused by Staphylococcus aureus (penicillinase and non-penicillinase-producing strains), Streptococcus pyogenes, Escherichia coli, Klebsiella spp., and Enterobacter spp. Urinary tract infections caused by Escherichia coli or Klebsiella pneumoniae. Bone and Joint infections caused by Staphylococcus aureus (penicillinase and non-penicillinase-producing strains). Gonorrhea Uncomplicated and disseminated gonococcal infections due to Neisseria gonorrhoeae (penicillinase and non penicillinase producing strains) in both males and females.

Antibacterial

Usual dose: The usual adult dosage range is 750 mg to 1.5 grams every 8 hours, usually for 5 to 10 days. In uncomplicated urinary tract infections, skin and skin-structure infections, disseminated gonococcal infections, and uncomplicated pneumonia, a 750-mg dose every 8 hours is recommended. In severe or complicated infections, a 1.5-gram dose every 8 hours is recommended. In bone and joint infections, a 1.5-gram dose every 8 hours is recommended. Surgical prophylaxis: A 1.5-gram dose administered intravenously just before surgery (approximately one-half to 1 hour before the initial incision) is recommended. Thereafter, give 750 mg intravenously or intramuscularly every 8 hours when the procedure is prolonged. Pediatric Patients Above 3 Months of Age: Administration of 50 to 100 mg/kg/day in equally divided doses every 6 to 8 hours has been successful for most infections susceptible to cefuroxime.

Patients with known allergy to cephalosporins & pseudomembranous colitis are contraindicated.

Generally Cefuroxime is well tolerated. However has been associated with nausea and vomiting in a small number of patients.

while all antibiotics should be avoided in the first trimester if possible. However, Cefuroxime has been safely used in later pregnancy to treat urinary and other infections. Cefuroxime is excreted through the breast milk in small quantity. However, the possibility of sensitizing the infant should be kept in mind.

Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics and who have history of colitis.

Store in a cool and dry place away from direct light. Keep out of reach of children Storage condition for reconstituted Injection: The reconstituted solutions are stable for 5 hours if stored at temperatures lower than 25°C and for 48 hours if stored at 4°C. Color intensification of reconstituted solution can be observed during storage.